Bitter Orange

What is It? It's a fruit common to Asia and also derived from germinating barley.
How It Works Extracts of Citrus Aurantuim include synephrine, octopamine, hordenine and tyramine. All four compounds stimulate the sympathetic nervous system similar, though with dramatically less "jitteriness" than ephedrine. That's because these compounds stimulate the beta-3 receptors of the nervous system which include the calorie burning effects with little or no effect on the beta 1 or beta 2 receptors. Beta 1 and beta 2 - those effected with ephedrine - have the potential to increase blood pressure, heart rate and nervousness.
The Research A stimulant classified as a Sympathomimetic amine which means it stimulates the same portion of the nervous system as caffeine and ephedra.
What Else To Know Citrus Aurantuim is said to prolong the effects of caffeine which has long been noted as a mild fat burner. Perhaps the two combined might be an effective fat burner as one study showed the duo added to the herb St John's Wort was very effective in shedding fat. Cost Dose Less than 10 cents a day to obtain 15 mgs daily.
Effectiveness Rating ****
Penzak, S.R., et al Seville (sour) orange juice: synepherine content and cardiovascular effects in normotensive adults. J Clin Pharmacol, 2001. Moro, C.O. and G. Basile. Obesity and medicinal plants. Fitoterapia, 2000.71 Suppl 1:p. S73-82p Colker, C, et al., Effects of citrus aurantium extract, caffeine and Saint-Johns' Wort on body fat loss, lipid levels and mood states in overweight healthy adults. Curr Ther Res 60(3):145-153.

Guarana

What is It? Source of caffeine. Caffeine, especially when used prior to exercise, increases the release of catecholamines, hormonal messengers that help breakd down body fat
How It Works Caffeine helps stimulate the fight or flight response which heps burn calories, spare the breakdown of protein and favor the burning of fatty acids from fat stores. The Research The research is overwhelming. Caffeine helps in body fat control : provided you are eating fewer calories than the body requires.
Effectiveness Rating **

Forskolin

What is It? Main ingredient of the herb coleus forskohlii How It Works Initiates fat burning by activating an enzyme called adenylate cyclase encouraging the use of fat. Mildly increase thyroid levels. The Research Most of the positive studies come from animal (rat) research. Anecdotally, seems to work well when taken with other fat burners. What Else To Know A member of the mint family and used in traditional medicines to treat indigestion and some heart ailments.
Effectiveness Rating ** (alone) *** (when combined with other ingredients found in Thermoloss)
Morimoto, C et al., Relationship between lipolysis induced by various lipolytic agents and hormone-sensitive lipase in rat fat cells. J. Lipid Res. Jan:42(1):120-7.

Phenylalanine

What is It? Amino acid
How It Works Increases adrenaline levels helping to trigger fat breakdown. Also helps control the appetite. The Research A few studies have shown phenylalanine to help control the appetite while others indicate it is one of the aminos that have the ability to increase growth hormone release, a major fat burning hormone.
Effectiveness Rating **
Rogers PJ. et al., Reanalysis of the effects of phenylalanine, alanine and aspartate on food intake in human subjects. Physiol Behav 1994; 56(2):247-50.

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